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• papers 28
• paper 28
• news 15
• blog 1
• data 2
• team 16
• projects 5
• project 5
• misc 2
• home 1

papers

• rstoolbox - a Python library for large-scale analysis of computational protein design data and structural bioinformatics
• Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen
• Rosetta FunFolDes - A general framework for the computational design of functional proteins
• Engineered anti-CRISPR proteins for optogenetic control of CRISPR-Cas9
• Structure-based immunogen design-leading the way to the new age of precision vaccines
• Computational protein design-the next generation tool to expand synthetic biology applications
• Global profiling of lysine reactivity and ligandability in the human proteome
• PRN473, an inhibitor of Bruton's tyrosine kinase, inhibits neutrophil recruitment via inhibition of macrophage antigen-1 signalling
• Chemoproteomic profiling and discovery of protein electrophiles in human cells
• Ligand and Target Discovery by Fragment-Based Screening in Human Cells
• Structural basis for nonneutralizing antibody competition at antigenic site II of the respiratory syncytial virus fusion protein
• Proteome-wide covalent ligand discovery in native biological systems
• Protein-protein structure prediction by scoring molecular dynamics trajectories of putative poses
• Motif-Driven Design of Protein-Protein Interfaces
• Integrating gene synthesis and microfluidic protein analysis for rapid protein engineering
• A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells
• Mapping the protein interaction landscape for fully functionalized small-molecule probes in human cells
• A computationally designed inhibitor of an Epstein-Barr viral Bcl-2 protein induces apoptosis in infected cells
• Proof of principle for epitope-focused vaccine design
• Reversion of somatic mutations of the respiratory syncytial virus-specific human monoclonal antibody Fab19 reveal a direct relationship between association rate and neutralizing potency
• Deciphering the molecular details for the binding of the prion protein to main ganglioside GM1 of neuronal membranes
• Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold
• High-resolution structure prediction of a circular permutation loop
• Solution structure of a minor and transiently formed state of a T4 lysozyme mutant
• Design and characterization of epitope-scaffold immunogens that present the motavizumab epitope from respiratory syncytial virus
• Computational protein design using flexible backbone remodeling and resurfacing- case studies in structure-based antigen design
• Computational design of epitope-scaffolds allows induction of antibodies specific for a poorly immunogenic HIV vaccine epitope
• A structural model of an amyloid protofilament of transthyretin

paper

• rstoolbox - a Python library for large-scale analysis of computational protein design data and structural bioinformatics
• Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen
• Rosetta FunFolDes - A general framework for the computational design of functional proteins
• Engineered anti-CRISPR proteins for optogenetic control of CRISPR-Cas9
• Structure-based immunogen design-leading the way to the new age of precision vaccines
• Computational protein design-the next generation tool to expand synthetic biology applications
• Global profiling of lysine reactivity and ligandability in the human proteome
• PRN473, an inhibitor of Bruton's tyrosine kinase, inhibits neutrophil recruitment via inhibition of macrophage antigen-1 signalling
• Chemoproteomic profiling and discovery of protein electrophiles in human cells
• Ligand and Target Discovery by Fragment-Based Screening in Human Cells
• Structural basis for nonneutralizing antibody competition at antigenic site II of the respiratory syncytial virus fusion protein
• Proteome-wide covalent ligand discovery in native biological systems
• Protein-protein structure prediction by scoring molecular dynamics trajectories of putative poses
• Motif-Driven Design of Protein-Protein Interfaces
• Integrating gene synthesis and microfluidic protein analysis for rapid protein engineering
• A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells
• Mapping the protein interaction landscape for fully functionalized small-molecule probes in human cells
• A computationally designed inhibitor of an Epstein-Barr viral Bcl-2 protein induces apoptosis in infected cells
• Proof of principle for epitope-focused vaccine design
• Reversion of somatic mutations of the respiratory syncytial virus-specific human monoclonal antibody Fab19 reveal a direct relationship between association rate and neutralizing potency
• Deciphering the molecular details for the binding of the prion protein to main ganglioside GM1 of neuronal membranes
• Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold
• High-resolution structure prediction of a circular permutation loop
• Solution structure of a minor and transiently formed state of a T4 lysozyme mutant
• Design and characterization of epitope-scaffold immunogens that present the motavizumab epitope from respiratory syncytial virus
• Computational protein design using flexible backbone remodeling and resurfacing- case studies in structure-based antigen design
• Computational design of epitope-scaffolds allows induction of antibodies specific for a poorly immunogenic HIV vaccine epitope
• A structural model of an amyloid protofilament of transthyretin

news

• Pablo Gainza-Cirauqui joins
• Internship student
• Invited talk
• Lab outing
• Novartis grant
• Seminar
• Che and Fabian join
• Masters' project student
• SNSF grant
• Systems X iPhD grant
• Interfaculty institute
• Novratis research grant
• Bruno invited for a talk
• Jaume Bonet joins
• Lab set up

blog

• A new site

data

• Disaggregation assay data visualization
• Aggregation assay data visualization

team

• Zander Harteveld
• Stéphane Rosset
• Sarah Wehrle
• Sandrine Georgeon
• Sailan Shui
• Pablo Gainza Cirauqui
• Mathieu Girardin
• Jaume Bonet Martinez
• Jane Marsden
• Freyr Sverrisson
• Fabienne Rudin
• Fabian Sesterhenn
• Che Yang
• Andreas Scheck
• Random alum
• Dr. Bruno Correia

projects

• Vaccine design
• Design of small molecule protein sensors
• Design of protein binders
• Development of Computational Methodologies for protein design
• Computation-guided in vitro evolution

project

• Vaccine design
• Design of small molecule protein sensors
• Design of protein binders
• Development of Computational Methodologies for protein design
• Computation-guided in vitro evolution

misc

• Laboratory of protein design & immunoengineering
• About

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